The accelerating determination of genome sequences and their interpretation (genomics) has brought with it one of the most daunting challenges to modern bioscience--the concomitant determination of the structure, function, and expression of the corresponding proteins encoded therein. The magnitude of this task is staggering. The difficulties arise at many stages, ranging from protein isolation and identification to structure determination, protein/protein interactions and gene expression, and the answers will require both existing technologies and methods yet to be developed. Thus, this rapidly expanding field of proteomics, a term coined in evident parallel to genomics, is both an extension of traditional biochemistry and at the same time a new and exciting field. Moreover, the magnitude of this effort will produce volumes of data that will dwarf previous outputs and pose severe problems in their own right. The storage, analysis and manipulation of this information, a problem already realized from genomic studies, has spawned a related field generally called bioinformatics. It is likely that these data sets will drive discovery and research that is unparalleled in the history of bioscience and could eclipse, at least in the early stages, hypothesis-driven experimentation. The management of research databases is not a new phenomenon, but the size of the task will require new and innovative approaches.
It is the primary objective of this publication to encourage the bridging of the gap between clinicians of all relevant specialities and biomedical scientists working in areas from biochemistry and molecular and cell biology to physiology, pharmacology and pathology. A spectrum of topics in medicine will be selected to illustrate not only the molecular insights that derive from the application of basic science, but also the variety of challenging problems that medicine is able to offer the basic scientist. The Editors and publisher anticipate that most of the authors contributing to the series will be practising clinical scientists who will develop their own personal perspective as an extended review on the molecular aspects of a field of medicine in which they are working, addressing themselves both to the doctor who is ill-at-ease with basic science, and to the basic scientist with little awareness of the problems of clinical practice.Benefits to authorsWe also provide many author benefits, such as free PDFs, a liberal copyright policy, special discounts on Elsevier publications and much more. Please click here for more information on our author services .Please see our Guide for Authors for information on article submission. If you require any further information or help, please visit our support pages: http://support.elsevier.com
Molecular Autism is a peer-reviewed, online open access journal that publishes high-quality basic, translational and clinical research into the molecular basis of autism and related neurodevelopmental conditions. Molecular Autism considers studies that relate causal and risk factors with these conditions, including research into genetics, molecular neurobiology, neuropathology, imaging and biomarkers, with a focus on potential applications for intervention.
Molecular Biology Reports is an international journal on molecular and cellular biology. The journal publishes both original research papers and (mini)-reviews. Among the fields of interest are DNA replication, transcription, nucleic acid-protein interaction, RNA processing, intracellular transport, protein biosynthesis, and related subjects. The journal publishes results of original research in clinically related biochemistry which approach the subject from a fundamental point of view. Papers on new techniques promoting experimental progress are also presented.
Molecular Biology and Evolution (MBE) publishes research at the interface between molecular and evolutionary biology. The journal publishes investigations of molecular evolutionary patterns and processes, tests of evolutionary hypotheses that use molecular data, and studies that use molecular evolutionary information to address questions about biological function at all levels of organization. Reports of work on comparative and evolutionary genomics and the evolution of molecular structure and function are particularly welcome.
MBoC publishes research articles and essays that report the results of original research and present conceptual advances of broad interest and significance within all areas of cell biology, genetics, and developmental biology. Manuscript submissions whose scope bridges several areas of cell and developmental biology are particularly encouraged. MBoC publishes articles that describe substantial research progress in full. Therefore, authors should include with their manuscript submissions all previously unpublished data and methods essential to support the conclusions drawn. MBoC does not, in general, publish articles that are narrow in scope and better suited to more specialized journals, merely confirmatory or preliminary reports of partially completed or incompletely documented research, findings of as yet uncertain significance, or reports that simply document well-known processes in organisms or cell types not previously studied. Submissions that report new methodologies will be considered only when a new result of biological significance has been achieved or when introduction of the method will significantly accelerate progress within a field.Note that MBoC places a premium on research articles that present conceptual advances of wide interest or deep mechanistic understanding of important CELLULAR processes. As such, articles dealing principally with describing behavior or modification of specific transcription factors, or analysis of the promoter elements through which they interact, will not generally be considered unless accompanied by information supporting in vivo relevance or broad significance.
Molecular Biotechnology publishes original research papers on the application of molecular biology to both basic and applied research in biotechnology. Particular areas of interest include the stability and expression of cloned gene products, cell transformation, gene cloning systems and the production of recombinant proteins, protein purification and analysis, transgenic species, developmental biology, mutation analysis, the applications of DNA fingerprinting, RNA interference, and PCR technology, microarray technology, proteomics, mass spectrometry, bioinformatics, plant molecular biology, microbial genetics, gene probes and the diagnosis of disease, pharmaceuticals, therapeutic agents, vaccines, gene targeting, gene therapy, stem cell technology and tissue engineering, antisense technology, protein engineering and enzyme technology, monoclonal antibodies, glycobiology and glycomics, and agricultural biotechnology. The journal also presents review articles on subjects in these areas.
Molecular Brain encompasses all aspects of the nervous system at the molecular, cellular, and system levels.
Molecular Breeding is an international journal focused on applications of plant molecular biology: research most likely leading to practical applications with demonstrable benefits for farmers, the seed and processing industries, the environment and the consumer in both the industrialized and the developing world. Papers chosen for publication contribute to the understanding and progress of modern plant breeding, encompassing the scientific disciplines of molecular biology, biochemistry, genetics, physiology, pathology, plant breeding and ecology, among others. Topics include contemporary methods of molecular genetics and genomic analysis, structural and functional genomics in crops, proteomics and metabolic profiling, abiotic stress and field evaluation of transgenic crops containing particular traits. The journal also publishes short communications, papers describing novel methods and review papers. All submissions are subject to peer review, ensuring the highest scientific standards.
Molecular Cancer Research publishes original, novel, and well-designed studies on the molecular and cellular aspects of cancer biology. Papers should represent significant new information gathered from basic research that has implications for cancer therapeutics in one of the following areas: Angiogenesis, Metastasis, and the Cellular Microenvironment; Cancer Genes and Genomics; Cell Cycle, Cell Death, and Senescence; DNA Damage and Cellular Stress Responses; Model Organisms; and Signaling and Regulation. All submissions are peer reviewed and only those that meet high standards of scientific merit will be accepted for publication.
Molecular Carcinogenesis presents information describing investigations of molecular aspects of the mechanisms involved in chemical, physical, and viral (biological) carcinogenesis. Areas of interest include, but are not limited to, the structure, expression, or function of genes or gene products associated with normal growth and differentiation and alterations in neoplasia; characterization of genes or gene products expressed in preneoplastic or neoplastic cells; molecular studies that define a specific function of a tumor-associated protein or its effects on cellular function; virtually all research on molecular aspects of oncogenes, tumor suppressor genes, and their gene products; carcinogenesis studies in transgenic mice; and research on human tumor viruses.
Molecular Cell is a companion to Cell, the leading journal of biology and the highest-impact journal in the world.Launched in December 1997 and published monthly, Molecular Cell defines the field of molecular biology with a relatively small number of significant papers, up to 15 articles per issue. Coverage will extend from structure to human diseases, concentrating on molecular analyses. Topics that will be represented in the first issues include gene expression, RNA processing, replication, recombination and repair, structure, chaperones, receptors, signal transduction, cell cycle, and tumorigenesis.The majority of papers published in Molecular Cell are articles in the format familiar from Cell. However, we will also publish short papers (up to 6 published pages) that make focused contributions on points of general interest. The publication schedule will be rapid: on our regular monthly schedule, publication time should average 6 weeks from acceptance.Visit the Molecular Cell website to find out more - http://www.molecule.org/
Molecular Cytogenetics encompasses all aspects of chromosome biology and the application of molecular cytogenetic techniques in all areas of biomedicine.
Molecular Diversity presents refereed papers describing the development, application and theory of molecular diversity, and combinatorial chemistry in basic and applied research and drug discovery. The journal publishes both short and full-length papers, perspectives, news and reviews. Coverage addresses the generation of molecular diversity, application of diversity for screening against alternative targets of all types, analysis of results and their application in various scientific disciplines. Topics include combinatorial chemistry and parallel synthesis; small molecule libraries; microwave synthesis; flow synthesis; fluorous synthesis; diversity oriented synthesis (DOS); nanoreactors; click chemistry; multiplex technologies; fragment- and ligand-based design; structure/function/SAR; computational chemistry and molecular design; chemoinformatics; screening techniques and screening interfaces; analytical and purification methods; robotics, automation and miniaturization; targeted libraries; display librar
Molecular Genetics & Genomic Medicine is a peer-reviewed journal for rapid dissemination of quality research related to the dynamically developing areas of human, molecular and medical genetics. The journal publishes original research articles covering findings in phenotypic, molecular, biological, and genomic aspects of genomic variation, inherited disorders and birth defects. The broad publishing spectrum of Molecular Genetics & Genomic Medicine includes rare and common disorders from diagnosis to treatment. Examples of appropriate articles include reports of novel disease genes, functional studies of genetic variants, in-depth genotype-phenotype studies, genomic analysis of inherited disorders, molecular diagnostic methods, medical bioinformatics, ethical, legal, and social implications (ELSI), and approaches to clinical diagnosis. Molecular Genetics & Genomic Medicine provides a scientific home for next generation sequencing studies of rare and common disorders, which will make research in this fascinating area easily and rapidly accessible to the scientific community. This will serve as the basis for translating next generation sequencing studies into individualized diagnostics and therapeutics, for day-to-day medical care.
Molecular Genetics & Genomic Medicine publishes original research articles, reviews, and research methods papers, along with invited editorials and commentaries. Original research papers must report well-conducted research with conclusions supported by the data presented.
Molecular Genetics & Genomic Medicine is a Wiley Open Access journal, one of a series of peer reviewed titles publishing quality research with speed and efficiency. Authors of accepted papers pay an Article Publication Charge and their papers are published under a Creative Commons license. With Creative Commons licenses, the author retains copyright and the public is allowed to reuse the content. The author grants Wiley a license to publish the article and identify as the original publisher. To find out which Created Commons Licenses are available for the journal, click here. For further information, visit the Wiley Open Access website.
The First Journal on Genetics, founded in 1908
Molecular Genetics and Genomics (MGG)Â publishes peer-reviewed articles covering all areas of genetics and genomics. Any approach to the study of genes and genomes is considered, be it experimental, theoretical or synthetic. MGG publishes research on all organisms that is of broad interest to those working in the fields of genetics, genomics, biology, medicine and biotechnology.
Molecular Genetics and Metabolism is a contribution to the understanding of the metabolic basis of disease. The journal publishes articles describing investigations that use the tools of biochemistry and molecular biology for studies of normal and diseased states. In addition to original research articles, occasional minireviews reporting timely advances as well as brief communications and letters to the editor are considered.Research Areas include:• Inherited Metabolic Diseases:- Biochemical studies of primary enzyme defects- Molecular genetic analyses of mutations- Pathogenesis of these disorders, including not only primary but also secondary metabolic alterations• Systems Biology:- Functional integration of biochemical network modules- Moonlighting functions of proteins• Intercellular and Intracellular Metabolic Relationships:- Biochemical interactions between cells- Functional roles of and interactions between subcellular compartments and distinct regions within these cellular spaces, termed microcompartments- Metabolic relations between individual enzymes and pathways• Cellular Catalysts:- Protein and nonprotein catalyst in normal and deranged cellular metabolism- Relationships between the structure and function of catalytic molecules- Interaction of these catalysts with other cellular components• Disease Pathogenesis:- Underlying mechanisms of inherited and acquired diseases- Relationships between genotype and phenotype at the biochemical and molecular levels• Treatment:- Drug, protein and dietary interventions- Transplantation and gene therapy- Multicenter clinical trialsAdvances in nanomedicine, nanopediatrics and nanotechnology are also welcome.